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Bacteria live in structured aggregates during chronic infections, where they evolve to adapt to the host environment in order to evade host immune responses and therapeutic interventions. Although we know how physical properties of the environment impact on aggregate formation, changes in bacterial surface properties on aggregate assembly have been overlooked. My research is focused on understanding the aggregate assembly of Pseudomonas aeruginosa in an in vitro sputum model. My findings highlight that O-antigen dictates aggregate assembly type, and sheds new light on the benefits or loss of O-antigen in polymer rich environments such as CF lungs.