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Spatiotemporal dynamics of phage-biofilm interactions by Hemaa Selvakumar (Curtis-Weitz Lab)
Bacteriophage (‘phage’) - viruses that infect and lyse bacteria - can be deployed therapeutically to treat infections caused by bacterial pathogens. However most reported studies of the therapeutic potential of phage neglect the spatial heterogeneity in bacterial communities, e.g., in microcolonies and biofilms. We investigate the spatiotemporal dynamics arising from interactions between P. aeruginosa and phage. Time-dependent high resolution confocal imaging is used to examine how phage propagate through spatial domains of bacteria and the resulting density-dependent structures that emerge.